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Biosynergy
(Europe) Ltd has five dedicated mammalian cell culture suites.
This provides plenty of flexibility
for growing different cell types and, where necessary, allows
us to run projects in isolation.
It also gives us scope for process and product development studies
without compromising other biomanufacturing activities. We have
experience of a wide range of cell culture techniques including
use of roller bottle, shaker flask, spinner vessel, cell factory,
miniperm, and stirred tank fermenters. We specialise in hollow
fibre bioreactor technology, which is well suited to antibody
production and recombinant protein production. The cell culture
technique we use is determined either by the production scale
(research, proof of concept, immunodiagnostic in-market supply)
or customer preference.
Prior to initiating a project, our cell culture team will work
with you to establish your requirements (e.g. process development,
amount of product, time constraints) and make sure that the
transfer of your cell cultures or biomanufacturing processes
into Biosynergy is as smooth and secure as possible. We can
create and manage your cell banks, confirm mycoplasma-free status,
test for other adventitious agents, clone your cells to improve
productivity and culture your cell lines to produce the protein
you require. We work closely with the protein purification team
to ensure that subsequent downstream processing proceeds smoothly
and efficiently.
We have over two decades experience of producing functional
biomolecules using hollow fibre bioreactors; this includes antibody
production (murine and humanised monoclonal antibodies) and
cytokines (Erythropoietin, GMCSF). With production capacity
of several hundred grammes a year we are able to work on a number
of projects simultaneously.
As a key supplier to companies in the immunodiagnostics sector
for many years, you are assured of a reliable, expert and consistent
service.
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