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The microbial
fermentation suite is equipped with 2 Applikon bioreactors.
Batch and fed-batch cultures of 5 to 15 litres can be produced
under stringently controlled conditions and we can quickly deliver
cell paste or conditioned medium.
We also produce cells in shake flasks using both small- and
medium-scale shaker incubators.
Constant monitoring of each run ensures pH, temperature, aeration,
dissolved oxygen content and agitation rate can be stringently
controlled to ensure that growth conditions are accurately reproduced
in order to provide product of a consistent quality. Quality
control is maintained by regular vessel sampling and metabolite
testing to ensure the final product meets customer specification.
Addition of nutrient and components during the run allows fed-batch
and induction experiments to be performed. Optimisation experiments
can also be performed, as regular sampling through a sterile
sample port is possible during the fermentation run.
Once harvested the cells can be sent as a frozen pellet or subjected
to further downstream processing to provide cell or protein
extracts specific to customer requirements.
Fermentation services include: batch or fed-batch fermentation;
cell harvesting to yield a concentrated cell paste.
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